As a CISO in healthcare, protecting patient data is a daily mission. Transparency, control, and adaptability are essential for cybersecurity strategies amongst changing geopolitical factors and the growing mix of threat actors globally. The cyber-attack on Change Healthcare put a spotlight on the need for robust defenses as increasing interconnectivity amplifies both opportunities and vulnerabilities. At Lilly, digital trust is a core principle, guiding efforts to monitor, detect, and mitigate risks, particularly as AI becomes a tool for both innovation and threats. By combining business controls with adaptive decision-making, Lilly is prioritizing safe technology use, ensuring tools evolve with advancements in technology, risk, and regulatory demands.