The clinical trial process is undergoing a digital rebuild, prompted by enablement, online tools, and the expanding patient health experience. Quickly forgotten are the clinical trial tribulations, such as recruitment, onsite encounters, and other logistical barriers. Decentralizing clinical trials is becoming the top method through use of robust, secure technology. Researchers can now remotely enroll, offer telehealth support, broaden their geographic scope of participants, and even execute on study protocols, unleashing the traditional “hub” research model for a modern digital architecture. Digital clinical trials also promise more robust data contributions to the effort, bridging the gaps between the vast, real world and a confined clinical setting. Join experts in the field as they reveal their blueprints to designing a digital clinical trial foundation while keeping a cautious eye to potential bottlenecks that may lie ahead.