Mount Sinai Health System has initiated an enterprise-wide deployment of OpenEvidence, an AI-powered medical search and clinical decision-support platform, integrated directly into its Epic electronic health record (EHR) system. The implementation represents OpenEvidence’s first large-scale rollout across a full clinical workforce, extending access beyond physicians to include registered nurses and pharmacists.
The platform is designed to function as a governed medical search engine, delivering responses grounded exclusively in peer-reviewed literature and established clinical guidelines. By ensuring that outputs are cited and evidence-based, the system aims to reduce risks commonly associated with generative AI, such as unsupported or inaccurate conclusions.
The integration into Epic addresses a longstanding workflow challenge in clinical environments. Traditional literature searches, such as those conducted through PubMed, are often impractical during real-time patient care. OpenEvidence allows clinicians to pose complex clinical questions in natural language and receive synthesized, citation-backed responses within the EHR interface. This approach eliminates the need to navigate external systems, a barrier that has historically limited adoption of digital decision-support tools.
Embedding the platform directly into clinical workflows is intended to improve usability and uptake. For example, pharmacists reviewing drug interactions or nurses seeking protocol guidance can access information without interrupting their workflow or switching applications.
The initiative also reflects a broader strategic shift toward expanding AI-enabled tools across multidisciplinary care teams. By providing enterprise-wide licensing, Mount Sinai aims to standardize access to clinical knowledge and support more consistent decision-making across roles.
Nicholas Gavin, Vice President and Chief Clinical Innovation Officer at Mount Sinai, stated, “Implementing OpenEvidence provides our pharmacists, nurses, and physicians with a unified, trusted platform for evidence-based decision-making. Our partnership… is a vital step in democratizing access to the latest clinical evidence for every member of the Mount Sinai care team.”
The deployment highlights ongoing efforts to operationalize clinical AI within existing healthcare infrastructure while maintaining a focus on reliability, accessibility, and workflow integration.
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