HHS Launches ‘OneHHS’ AI Strategy to Unite CDC, CMS & FDA for Efficiency and Trust

The U.S. Department of Health and Human Services (HHS) has released its first comprehensive AI Strategy, advancing a department-wide plan to integrate artificial intelligence across all major divisions—including the CDC, CMS, FDA, and NIH. The move fulfills the Trump Administration’s mandate to modernize federal health operations by adopting leading technologies to improve efficiency, strengthen innovation, and enhance patient outcomes. Deputy Secretary Jim O’Neill said AI has the potential to “revolutionize health care and human services,” and HHS intends to lead that transformation.

At the center of the strategy is the new “OneHHS” approach, which unifies all HHS agencies under a shared AI infrastructure for the first time. By centralizing technology, HHS aims to streamline workflows, increase cybersecurity, and modernize the country’s public health systems. The framework is built on five strategic pillars: strengthening governance and risk management; designing infrastructure around user needs; developing the federal workforce and reducing administrative burden; enabling reproducible, high-quality scientific research; and modernizing clinical and public health delivery. Acting Chief Artificial Intelligence Officer Clark Minor emphasized that the goal is to use AI to empower staff and drive innovation across all HHS operations.

Although the initial focus is internal modernization, HHS has made clear that this strategy is meant to eventually expand collaboration with the private sector. Technology companies developing health AI tools will play a key role in future joint solutions, as the “OneHHS” framework will standardize how federal agencies evaluate, adopt, and interface with private AI innovations.